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Interactions médicamenteuses

Argatroban + Prasugrel

Gravité: Majeure

Argatroban and Prasugrel: major interaction.

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Résumé

Prasugrel is a potent P2Y12 antiplatelet and argatroban is a direct thrombin inhibitor. Used together they significantly increase the risk of serious bleeding.

Ce que signifie cette interaction, en termes simples

Argatroban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Argatroban belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic effect from platelet P2Y12 inhibition and thrombin inhibition.

Conduite à tenir

Use together only when clearly indicated, such as during PCI, and minimize duration. Monitor hemoglobin, aPTT or ACT, and for bleeding.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Argatroban with Prasugrel?

MediHelp rates the interaction as major. Argatroban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent P2Y12 antiplatelet and argatroban is a direct thrombin inhibitor. Used together they significantly increase the risk of serious bleeding.

How serious is the interaction between Argatroban and Prasugrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly indicated, such as during PCI, and minimize duration. Monitor hemoglobin, aPTT or ACT, and for bleeding.

What other medicines interact with Argatroban?

MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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