Interactions médicamenteuses
Dabigatran etexilate + Prasugrel
Gravité: Majeure
Dabigatran etexilate and Prasugrel: major interaction.
Dernière mise à jour
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Résumé
Combining a direct thrombin inhibitor with a potent P2Y12 antiplatelet markedly raises the risk of major bleeding, including gastrointestinal and intracranial hemorrhage. Prasugrel carries its own high bleeding risk, particularly in older or low-weight patients.
Ce que signifie cette interaction, en termes simples
Dabigatran etexilate and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
Pourquoi elle survient
Additive effects on hemostasis: dabigatran inhibits thrombin while prasugrel irreversibly inhibits platelet P2Y12 receptors.
Conduite à tenir
Use only when clearly indicated and for the shortest duration; consider a less potent P2Y12 inhibitor such as clopidogrel and add gastroprotection. Monitor hemoglobin and for bleeding signs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contre-indiquée
- Dabigatran etexilate + Ketorolac Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
- Abciximab + Dabigatran etexilate Majeure
- Alteplase + Dabigatran etexilate Majeure
- Amiodarone + Dabigatran etexilate Majeure
Autres interactions de Prasugrel
- Acetylsalicylic acid + Prasugrel Majeure
- Apixaban + Prasugrel Majeure
- Argatroban + Prasugrel Majeure
- Cangrelor + Prasugrel Majeure
- Celecoxib + Prasugrel Majeure
- Dalteparin + Prasugrel Majeure
Questions fréquentes
Can I take Dabigatran etexilate with Prasugrel?
MediHelp rates the interaction as major. Dabigatran etexilate and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a direct thrombin inhibitor with a potent P2Y12 antiplatelet markedly raises the risk of major bleeding, including gastrointestinal and intracranial hemorrhage. Prasugrel carries its own high bleeding risk, particularly in older or low-weight patients.
How serious is the interaction between Dabigatran etexilate and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when clearly indicated and for the shortest duration; consider a less potent P2Y12 inhibitor such as clopidogrel and add gastroprotection. Monitor hemoglobin and for bleeding signs.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
