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Interactions médicamenteuses

Celecoxib + Prasugrel

Gravité: Majeure

Celecoxib and Prasugrel: major interaction.

Dernière mise à jour

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Résumé

Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.

Ce que signifie cette interaction, en termes simples

Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Celecoxib belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive effect of irreversible P2Y12 platelet inhibition and NSAID-related platelet dysfunction and mucosal injury.

Conduite à tenir

Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Celecoxib with Prasugrel?

MediHelp rates the interaction as major. Celecoxib and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with prasugrel increases the risk of bleeding, particularly gastrointestinal bleeding. Prasugrel already carries a substantial bleeding risk.

How serious is the interaction between Celecoxib and Prasugrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use where possible and use paracetamol as an alternative. If needed, use the lowest celecoxib dose briefly with a proton pump inhibitor and monitor for bleeding.

What other medicines interact with Celecoxib?

MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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