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Interactions médicamenteuses

Apixaban + Prasugrel

Gravité: Majeure

Apixaban and Prasugrel: major interaction.

Dernière mise à jour

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Résumé

Prasugrel is a potent antiplatelet and apixaban is an anticoagulant. Together they substantially increase the risk of major bleeding.

Ce que signifie cette interaction, en termes simples

Apixaban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apixaban belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive hemostatic impairment from irreversible P2Y12 inhibition and factor Xa inhibition.

Conduite à tenir

Avoid unless clearly indicated. In patients needing both, clopidogrel is generally preferred with an anticoagulant.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apixaban with Prasugrel?

MediHelp rates the interaction as major. Apixaban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet and apixaban is an anticoagulant. Together they substantially increase the risk of major bleeding.

How serious is the interaction between Apixaban and Prasugrel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated. In patients needing both, clopidogrel is generally preferred with an anticoagulant.

What other medicines interact with Apixaban?

MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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