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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Dacomitinib + Flecainide

Gravité: Majeure

Dacomitinib and Flecainide: major interaction.

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Résumé

Dacomitinib strongly inhibits CYP2D6, which is a main route of flecainide metabolism. Flecainide levels may therefore rise, increasing the risk of conduction abnormalities and proarrhythmia because it has a narrow therapeutic index.

Ce que signifie cette interaction, en termes simples

Dacomitinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dacomitinib belongs to Oncology; Flecainide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Dacomitinib inhibits CYP2D6, reducing flecainide clearance.

Conduite à tenir

Avoid the combination where possible. If it cannot be avoided, monitor the ECG and flecainide plasma concentrations, and reduce the flecainide dose as needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dacomitinib with Flecainide?

MediHelp rates the interaction as major. Dacomitinib and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib strongly inhibits CYP2D6, which is a main route of flecainide metabolism. Flecainide levels may therefore rise, increasing the risk of conduction abnormalities and proarrhythmia because it has a narrow therapeutic index.

How serious is the interaction between Dacomitinib and Flecainide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, monitor the ECG and flecainide plasma concentrations, and reduce the flecainide dose as needed.

What other medicines interact with Flecainide?

MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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