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Interactions médicamenteuses

Deflazacort + Somatrogon

Gravité: Modérée

Deflazacort and Somatrogon: moderate interaction.

Dernière mise à jour

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Résumé

High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.

Ce que signifie cette interaction, en termes simples

Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Deflazacort belongs to Miscellaneous; Somatrogon belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Pharmacodynamic antagonism of growth hormone by glucocorticoids and growth hormone inhibition of 11-beta-HSD1.

Conduite à tenir

Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deflazacort with Somatrogon?

MediHelp rates the interaction as moderate. Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.

How serious is the interaction between Deflazacort and Somatrogon?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.

What other medicines interact with Deflazacort?

MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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