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Interactions médicamenteuses

Glycerol phenylbutyrate + Hydrocortisone

Gravité: Modérée

Glycerol phenylbutyrate and Hydrocortisone: moderate interaction.

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Résumé

Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.

Ce que signifie cette interaction, en termes simples

Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Glycerol phenylbutyrate belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Corticosteroid-induced protein breakdown increases nitrogen load and ammonia production, counteracting nitrogen scavenging.

Conduite à tenir

Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Glycerol phenylbutyrate with Hydrocortisone?

MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism, which can raise plasma ammonia. This opposes the ammonia-lowering goal of glycerol phenylbutyrate in urea cycle disorders and risks hyperammonemia.

How serious is the interaction between Glycerol phenylbutyrate and Hydrocortisone?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing hydrocortisone dose. Adjust glycerol phenylbutyrate and dietary protein as advised by the metabolic team.

What other medicines interact with Hydrocortisone?

MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.

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