Interazioni tra farmaci
Amlodipine-benazepril + Isosorbide dinitrate
Gravità: Moderata
Amlodipine-benazepril and Isosorbide dinitrate: moderate interaction.
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Sintesi
Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
Cosa significa questa interazione in parole semplici
Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Isosorbide dinitrate belongs to Cardiovascular.
Perché avviene
Additive vasodilation through nitric oxide-mediated smooth muscle relaxation, calcium channel blockade and reduced angiotensin II.
Cosa fare
Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Controindicata
- Amlodipine-benazepril + Sacubitril / valsartan Controindicata
- Aldesleukin + Amlodipine-benazepril Maggiore
- Amifostine + Amlodipine-benazepril Maggiore
- Amiloride + Amlodipine-benazepril Maggiore
- Amlodipine-benazepril + Azilsartan Maggiore
Altre interazioni di Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide dinitrate + Sildenafil Controindicata
- Isosorbide dinitrate + Tadalafil Controindicata
- Isosorbide dinitrate + Vardenafil Controindicata
- Ergotamine + Isosorbide dinitrate Maggiore
Domande frequenti
Can I take Amlodipine-benazepril with Isosorbide dinitrate?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Isosorbide dinitrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates cause venous and arterial dilation, and adding amlodipine and benazepril increases the likelihood of symptomatic hypotension, dizziness or syncope. The effect is often tolerated but is more notable in older or volume-depleted patients.
How serious is the interaction between Amlodipine-benazepril and Isosorbide dinitrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing doses. Adjust doses of antihypertensives if hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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