Interazioni tra farmaci
Bupropion + Cefpirome
Gravità: Moderata
Bupropion and Cefpirome: moderate interaction.
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Sintesi
Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
Cosa significa questa interazione in parole semplici
Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cefpirome belongs to Anti Bacterial.
Perché avviene
Additive lowering of seizure threshold (cephalosporin GABA-A antagonism plus bupropion's proconvulsant effect).
Cosa fare
Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Bupropion
- Bupropion + Isocarboxazid Controindicata
- Bupropion + Linezolid Controindicata
- Bupropion + Phenelzine Controindicata
- Bupropion + Rasagiline Controindicata
- Bupropion + Selegiline Controindicata
- Bupropion + Selegiline transdermal Controindicata
Altre interazioni di Cefpirome
- Amikacin + Cefpirome Moderata
- Bupropion-naltrexone + Cefpirome Moderata
- Cefpirome + Dexamethasone-tobramycin Moderata
- Cefpirome + Gentamicin Moderata
- Cefpirome + Streptomycin Moderata
- Acetylsalicylic acid + Cefpirome Minore
Domande frequenti
Can I take Bupropion with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.
How serious is the interaction between Bupropion and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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