Interazioni tra farmaci
Dexmethylphenidate + Procarbazine
Gravità: Controindicata
Dexmethylphenidate and Procarbazine: contraindicated interaction.
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Sintesi
Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
Cosa significa questa interazione in parole semplici
Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Procarbazine belongs to Oncology.
Perché avviene
MAO inhibition increases stores of catecholamines, so the sympathomimetic effects of the stimulant are exaggerated.
Cosa fare
Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amoxapine + Procarbazine Controindicata
- Atomoxetine + Procarbazine Controindicata
- Bcg vaccine live + Procarbazine Controindicata
- Brimonidine + Procarbazine Controindicata
Altre interazioni di Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Controindicata
- Dexmethylphenidate + Linezolid Controindicata
- Dexmethylphenidate + Phenelzine Controindicata
- Dexmethylphenidate + Rasagiline Controindicata
- Dexmethylphenidate + Safinamide Controindicata
- Dexmethylphenidate + Selegiline Controindicata
Domande frequenti
Can I take Dexmethylphenidate with Procarbazine?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
How serious is the interaction between Dexmethylphenidate and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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