Interazioni tra farmaci
Isocarboxazid + Naratriptan
Gravità: Maggiore
Isocarboxazid and Naratriptan: major interaction.
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Sintesi
Isocarboxazid irreversibly inhibits monoamine oxidase and naratriptan is a 5-HT1B/1D agonist. Both increase serotonergic or vasoconstrictor tone, so serotonin syndrome or hypertensive effects are possible, although naratriptan is not mainly cleared by MAO.
Cosa significa questa interazione in parole semplici
Isocarboxazid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Perché avviene
Additive serotonergic and vasoconstrictor effects
Cosa fare
Avoid where possible; if used, give naratriptan at the lowest dose and monitor blood pressure and for serotonin toxicity.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Altre interazioni di Naratriptan
- Almotriptan + Naratriptan Controindicata
- Dihydroergotamine intranasal + Naratriptan Controindicata
- Dihydroergotamine + Naratriptan Controindicata
- Eletriptan + Naratriptan Controindicata
- Ergoloid mesylates + Naratriptan Controindicata
- Ergotamine + Naratriptan Controindicata
Domande frequenti
Can I take Isocarboxazid with Naratriptan?
MediHelp rates the interaction as major. Isocarboxazid and Naratriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isocarboxazid irreversibly inhibits monoamine oxidase and naratriptan is a 5-HT1B/1D agonist. Both increase serotonergic or vasoconstrictor tone, so serotonin syndrome or hypertensive effects are possible, although naratriptan is not mainly cleared by MAO.
How serious is the interaction between Isocarboxazid and Naratriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if used, give naratriptan at the lowest dose and monitor blood pressure and for serotonin toxicity.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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