Riferimento farmaci
Riociguat
Riociguat is a medicine in the class cardiovascular. It is used for pulmonary hypertension.
- Classe del farmaco: Cardiovascular
- Indicato per: pulmonary hypertension
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Cardiovascular
- Codice ATC
- C02KX05
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 0.5 mg
- Interazioni note
- 79 (Controindicata: 9 · Maggiore: 9 · Moderata: 49 · Minore: 12)
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Stimulator of soluble guanylate cyclase (sGC). It sensitizes sGC to endogenous nitric oxide and also directly stimulates sGC independently of NO, increasing cGMP and causing vasodilation.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
CTEPH or PAH: start 1 mg orally three times a day (consider 0.5 mg three times a day if hypotension may not be tolerated); if systolic BP stays above 95 mmHg with no hypotension symptoms, increase by 0.5 mg three times a day no sooner than every 2 weeks; maximum 2.5 mg three times a day
Gravidanza e allattamento
- Gravidanza
- Unsafe Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited.
- Allattamento
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
Effetti indesiderati segnalati
- Headache
- Dyspepsia and gastritis
- Dizziness
- Nausea
- Diarrhea
- Hypotension
Avvertenze in evidenza
- Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data. Exclude pregnancy before treatment. Use effective contraception before, during and for one month after treatment. If pregnancy is detected, discontinue as soon as possible.
Controindicazioni
- Pregnancy
- Concomitant nitrates or nitric oxide donors in any form
- Concomitant PDE inhibitors (specific PDE-5 inhibitors and nonspecific such as dipyridamole or theophylline)
Chi deve prestare attenzione
- Hypotension: reduces blood pressure; consider risk in hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, antihypertensives or strong CYP/P-gp/BCRP inhibitors; consider dose reduction.
- Bleeding: serious bleeding occurred in 2.4% of patients on Adempas vs 0% placebo, including serious hemoptysis in 1%.
- Pulmonary veno-occlusive disease: not recommended; if pulmonary edema occurs, consider PVOD and discontinue if confirmed.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (79)
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
- Riociguat + Tadalafil Contraindicated
- Riociguat + Theophylline Contraindicated
- Riociguat + Vardenafil Contraindicated
- Apalutamide + Riociguat Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Domande frequenti
What is Riociguat used for?
Riociguat is a medicine in the class cardiovascular. It is used for Pulmonary hypertension.
What side effects have been reported with Riociguat?
Headache, Dyspepsia and gastritis, Dizziness, Nausea, Diarrhea, Hypotension. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data.
Can Riociguat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
What does Riociguat interact with?
MediHelp lists 79 known interactions for Riociguat. Contraindicated: 9 · Major: 9 · Moderate: 49 · Minor: 12. The most serious include Avanafil, Dipyridamole, Isosorbide dinitrate.
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