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Riociguat + Sildenafil

Gravità: Controindicata

Riociguat and Sildenafil: contraindicated interaction.

Ultimo aggiornamento Fonti: US FDA label

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Sintesi

Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.

Cosa significa questa interazione in parole semplici

Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Riociguat belongs to Cardiovascular; Sildenafil belongs to Genitourinary.

Livello di evidenza: High

Perché avviene

Riociguat stimulates soluble guanylate cyclase to raise cGMP, and sildenafil blocks cGMP degradation via PDE5, so the effects on the nitric oxide-cGMP pathway are additive.

Cosa fare

Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Riferimenti

Domande frequenti

Can I take Riociguat with Sildenafil?

MediHelp rates the interaction as contraindicated. Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.

How serious is the interaction between Riociguat and Sildenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.

What other medicines interact with Riociguat?

MediHelp also lists interactions of Riociguat with, for example, Avanafil, Dipyridamole, Isosorbide dinitrate. The full list is on the Riociguat page.

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