Interazioni tra farmaci
Avanafil + Riociguat
Gravità: Controindicata
Avanafil and Riociguat: contraindicated interaction.
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Sintesi
Riociguat with avanafil may produce additive systemic vasodilation and symptomatic hypotension. PDE5 inhibitors are contraindicated with riociguat by labeling.
Cosa significa questa interazione in parole semplici
Avanafil and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Riociguat belongs to Cardiovascular.
Perché avviene
Riociguat stimulates soluble guanylate cyclase to increase cGMP while avanafil inhibits its degradation, causing additive vasodilation.
Cosa fare
Do not coadminister; select one agent for the indication. Follow labeled washout intervals when switching.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Avanafil
- Amyl nitrite + Avanafil Controindicata
- Atazanavir + Avanafil Controindicata
- Avanafil + Clarithromycin Controindicata
- Avanafil + Conivaptan Controindicata
- Avanafil + Darunavir Controindicata
- Avanafil + Fosamprenavir Controindicata
Altre interazioni di Riociguat
- Dipyridamole + Riociguat Controindicata
- Isosorbide dinitrate + Riociguat Controindicata
- Isosorbide mononitrate + Riociguat Controindicata
- Nitroglycerin + Riociguat Controindicata
- Riociguat + Sildenafil Controindicata
- Riociguat + Tadalafil Controindicata
Domande frequenti
Can I take Avanafil with Riociguat?
MediHelp rates the interaction as contraindicated. Avanafil and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat with avanafil may produce additive systemic vasodilation and symptomatic hypotension. PDE5 inhibitors are contraindicated with riociguat by labeling.
How serious is the interaction between Avanafil and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select one agent for the indication. Follow labeled washout intervals when switching.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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