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Glatiramer

Glatiramer is a medicine in the class central nervous system. It is used for multiple sclerosis.

最終更新日 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Central Nervous System
一般的な剤形
注射剤
一般的な規格
20 mg/ml, 40 mg/ml
既知の相互作用
18 (軽度: 18)
商品名
4
国・市場
2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

作用のしくみ

Mechanism in MS is not fully understood; thought to act by modifying immune processes believed responsible for MS pathogenesis. Animal and in vitro studies suggest induction and activation of glatiramer acetate-specific suppressor T-cells in the periphery.

成人の通常用量（添付文書の要約）

Relapsing forms of multiple sclerosis: Glatopa 20 mg per mL, subcutaneous, once per day

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unknown Pharmacovigilance and observational data have not identified a drug-associated risk of major birth defects, miscarriage, or adverse outcomes; no adverse effects in rats or rabbits.
授乳
Unknown No data on presence in human milk; low systemic exposure means clinically relevant infant exposure is not expected. Weigh benefits of breastfeeding against maternal need.

報告されている副作用

  • Injection site erythema
  • Injection site pain
  • Injection site pruritus
  • Injection site mass
  • Vasodilatation
  • Rash

警告（枠囲み警告）

  • Life-threatening and fatal anaphylaxis has been reported, and can occur at any time after starting therapy, from after the first dose to years later. Make patients aware of symptoms, which may overlap with immediate post-injection reaction, and instruct them to seek immediate medical care. Contraindicated in patients with prior hypersensitivity, including anaphylaxis. If anaphylaxis occurs, discontinue immediately and permanently unless a clear alternative etiology is identified.

禁忌

  • Known hypersensitivity to glatiramer acetate or mannitol; reactions have included anaphylaxis.

注意が必要な方

  • Immediate post-injection reaction (flushing, chest pain, palpitations, tachycardia, anxiety, dyspnea, throat constriction, urticaria) may occur within seconds to minutes after injection; usually transient.
  • Transient chest pain may occur, often unrelated to injection.
  • Lipoatrophy and rarely skin necrosis may occur at injection sites; lipoatrophy is thought to be permanent. Use proper technique and rotate sites.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (18)

All 18 interactions, with severity and what to do

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  • How to give it
  • Pharmacokinetics
  • Patient counselling points
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同じ分類のほかの薬剤

よくある質問

What is Glatiramer used for?

Glatiramer is a medicine in the class central nervous system. It is used for Multiple sclerosis.

What side effects have been reported with Glatiramer?

Injection site erythema, Injection site pain, Injection site pruritus, Injection site mass, Vasodilatation, Rash. Serious warning: Life-threatening and fatal anaphylaxis has been reported, and can occur at any time after starting therapy, from after the first dose to years later.

Can Glatiramer be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. Pharmacovigilance and observational data have not identified a drug-associated risk of major birth defects, miscarriage, or adverse outcomes; no adverse effects in rats or rabbits. Breastfeeding: Unknown. No data on presence in human milk; low systemic exposure means clinically relevant infant exposure is not expected. Weigh benefits of breastfeeding against maternal need.

What does Glatiramer interact with?

MediHelp lists 18 known interactions for Glatiramer. Minor: 18. The most serious include Anakinra, Anti-thymocyte, Basiliximab.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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