医薬品リファレンス
Monomethyl fumarate
Monomethyl fumarate is a medicine in the class central nervous system. It is used for multiple sclerosis.
- 薬効分類: Central Nervous System
- 効能・効果: multiple sclerosis
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Central Nervous System
何に使われるか
作用のしくみ
The mechanism in multiple sclerosis is unknown. MMF activates the Nrf2 pathway (response to oxidative stress) and is a nicotinic acid receptor agonist in vitro.
成人の通常用量（添付文書の要約）
Relapsing forms of multiple sclerosis: starting dose 95 mg orally twice a day for 7 days, then maintenance 190 mg (two 95 mg capsules) orally twice a day.
妊娠と授乳
- 妊娠
- Unknown Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed.
- 授乳
- Safe No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
報告されている副作用
- Flushing
- Abdominal pain
- Diarrhea
- Nausea
- Vomiting
- Pruritus
禁忌
- Known hypersensitivity to monomethyl fumarate, dimethyl fumarate, diroximel fumarate, or any excipient (reactions may include anaphylaxis or angioedema).
- Concomitant use with dimethyl fumarate or diroximel fumarate.
注意が必要な方
- Anaphylaxis and angioedema can occur after the first dose or at any time; discontinue and do not restart.
- PML: withhold at the first sign or symptom suggestive of PML.
- Herpes zoster and other serious opportunistic infections: consider withholding until the infection resolves.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
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アカウントを作成してPro+トライアルを始めると、Monomethyl fumarateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Monomethyl fumarate used for?
Monomethyl fumarate is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Monomethyl fumarate?
Flushing, Abdominal pain, Diarrhea, Nausea, Vomiting, Pruritus.
Can Monomethyl fumarate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Registry data for dimethyl fumarate (its prodrug) show no rise in birth defects or miscarriage; most exposures were in the 1st trimester. In animals, offspring survival, growth and behaviour were affected at clinically relevant doses. Use only if needed. Breastfeeding: Safe. No direct data, but it is the active form of dimethyl fumarate: low milk levels and data in over 20 infants show no harm, so LactMed finds it acceptable, at least after 1 month of age. US label: weigh benefits. Monitor infant weight gain.
What does Monomethyl fumarate interact with?
MediHelp does not list a checked interaction for Monomethyl fumarate yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
