医薬品リファレンス
Interferon beta 1a
Interferon beta 1a is a medicine in the class central nervous system. It is used for multiple sclerosis.
- 薬効分類: Central Nervous System
- 効能・効果: multiple sclerosis
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Central Nervous System
- ATCコード
- L03AB07
- 一般的な剤形
- 注射剤
- 一般的な規格
- 30 mcg/.5 ml, 22 mcg/0.5 ml, 30 mcg
- 既知の相互作用
- 18 (重大: 9 · 中等度: 8 · 軽度: 1)
- 商品名
- 10
- 国・市場
- 3
何に使われるか
作用のしくみ
Recombinant interferon; antiviral, antiproliferative, immunoregulatory protein; alters response to surface antigen and may enhance immune cell activities
成人の通常用量（添付文書の要約）
Avonex: 30 mcg IM qWk, starting with 7.5 mcg IM for first week, to reduce flu-like symptoms; increase by 7.5 mcg/week for next 3 weeks until recommended dose of 30 mcg/week
妊娠と授乳
- 妊娠
- Safe Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist.
- 授乳
- Safe Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
報告されている副作用
- Headache
- Nausea
- Injection site reactions
- Flu-like syndrome
- Muscle ache
- URT infection
注意が必要な方
- Thyroid function should be monitored periodically If patients have or develop symptoms of thyroid dysfunction (hypo- or hyperthyroidism),
- Seizures have been temporally associated with use of beta interferons in clinical trials and postmarketing safety surveillance
- Cases of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, some fatal, have been reported
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (18)
- Deferiprone + Interferon beta 1a Major
- Etrasimod + Interferon beta 1a Major
- Hydroxyurea + Interferon beta 1a Major
- Idecabtagene vicleucel + Interferon beta 1a Major
- Interferon beta 1a + Lisocabtagene maraleucel Major
- Interferon beta 1a + Pexidartinib Major
- Interferon beta 1a + Pretomanid Major
- Interferon beta 1a + Ropeginterferon alfa 2b Major
- Interferon beta 1a + Tisagenlecleucel Major
- Acalabrutinib + Interferon beta 1a Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Interferon beta 1aの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Interferon beta 1a used for?
Interferon beta 1a is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Interferon beta 1a?
Headache, Nausea, Injection site reactions, Flu-like syndrome, Muscle ache, URT infection.
Can Interferon beta 1a be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist. Breastfeeding: Safe. Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
What does Interferon beta 1a interact with?
MediHelp lists 18 known interactions for Interferon beta 1a. Major: 9 · Moderate: 8 · Minor: 1. The most serious include Deferiprone, Etrasimod, Hydroxyurea.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
