医薬品リファレンス
Tetracycline
Tetracycline is a medicine in the class anti bacterial. It is used for acne.
- 薬効分類: Anti Bacterial
- 効能・効果: acne
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Bacterial
- 一般的な剤形
- 軟膏剤, カプセル剤, スプレー剤, 溶液, 注射剤
- 一般的な規格
- 250 mg, 30 mg/ml, 3%
- 既知の相互作用
- 108 (併用禁忌: 2 · 重大: 5 · 中等度: 72 · 軽度: 29)
- 商品名
- 29
- 国・市場
- 4
何に使われるか
作用のしくみ
Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunit(s)
成人の通常用量（添付文書の要約）
Chronic Bronchitis, Acute Exacerbation (Usual daily dose): 500 mg PO q12hr or 250 mg PO q6hr (ie, 1000 mg/day)
妊娠と授乳
- 妊娠
- Unsafe Tetracyclines can permanently stain the baby's teeth and affect bone growth once tooth mineralisation starts (about 15-16 weeks), and high doses have caused serious liver toxicity in pregnant women. Avoid in pregnancy; use a safer antibiotic. Skin or eye use gives little absorption.
- 授乳
- Safe Labels advise avoiding breastfeeding. LactMed is more reassuring: milk levels are low and milk calcium limits absorption, so short courses are probably acceptable; avoid prolonged or repeated courses. Watch the infant for rash, diarrhoea or thrush.
報告されている副作用
- Nausea
- Anorexia
- Hemolytic anemia
- Permanent discoloration of teeth
- Increased BUN (dose-related)
禁忌
- Documented hypersensitivity
- Severe hepatic dysfunction
- Pregnancy 2nd and 3rd trimesters
注意が必要な方
- Consider drug serum level determinations in prolonged therapy
- Antianabolic action of the tetracyclines may cause an increase in BUN; in patients with significantly impaired renal function.
- Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracyclines
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (108)
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
- Tetracycline + Typhoid vaccine live Major
- Aluminum hydroxide + Tetracycline Moderate
- Aminolevulinic acid + Tetracycline Moderate
- Amoxicillin-clavulanic acid + Tetracycline Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Tetracyclineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Tetracycline used for?
Tetracycline is a medicine in the class anti bacterial. It is used for Acne, Bronchitis, Brucellosis, Gonorrhea, Syphilis.
What side effects have been reported with Tetracycline?
Nausea, Anorexia, Hemolytic anemia, Permanent discoloration of teeth, Increased BUN (dose-related).
Can Tetracycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Tetracyclines can permanently stain the baby's teeth and affect bone growth once tooth mineralisation starts (about 15-16 weeks), and high doses have caused serious liver toxicity in pregnant women. Avoid in pregnancy; use a safer antibiotic. Skin or eye use gives little absorption. Breastfeeding: Safe. Labels advise avoiding breastfeeding. LactMed is more reassuring: milk levels are low and milk calcium limits absorption, so short courses are probably acceptable; avoid prolonged or repeated courses. Watch the infant for rash, diarrhoea or thrush.
What does Tetracycline interact with?
MediHelp lists 108 known interactions for Tetracycline. Contraindicated: 2 · Major: 5 · Moderate: 72 · Minor: 29. The most serious include Acitretin, Methoxyflurane, Isotretinoin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
