相互作用
Amisulpride + Bromocriptine
重症度: 重大
Amisulpride and Bromocriptine: major interaction.
最終更新日
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概要
Amisulpride is a selective D2/D3 receptor antagonist and opposes the dopaminergic action of bromocriptine. This can reduce control of Parkinson disease or hyperprolactinemia, and the agonist may in turn worsen psychosis.
この相互作用をわかりやすく説明すると
Amisulpride and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Bromocriptine belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism at dopamine D2/D3 receptors.
対処法
Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, and monitor symptoms and prolactin if both must be used.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとBromocriptineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bromocriptineのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Bromocriptine?
MediHelp rates the interaction as major. Amisulpride and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride is a selective D2/D3 receptor antagonist and opposes the dopaminergic action of bromocriptine. This can reduce control of Parkinson disease or hyperprolactinemia, and the agonist may in turn worsen psychosis.
How serious is the interaction between Amisulpride and Bromocriptine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, and monitor symptoms and prolactin if both must be used.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Bromocriptine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
