相互作用
Apalutamide + Tinidazole
重症度: 中等度
Apalutamide and Tinidazole: moderate interaction.
最終更新日
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概要
Apalutamide is a strong CYP3A4 inducer and may lower tinidazole concentrations, since CYP3A4 contributes to tinidazole metabolism. Reduced exposure could lead to treatment failure of the infection.
この相互作用をわかりやすく説明すると
Apalutamide and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Tinidazole belongs to Anti Parasitic.
なぜ起こるのか
Induction of CYP3A4 by apalutamide increases tinidazole metabolism.
対処法
Monitor for clinical response to tinidazole and consider an alternative antimicrobial if response is inadequate.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとTinidazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tinidazoleのその他の相互作用
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Tinidazole?
MediHelp rates the interaction as moderate. Apalutamide and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and may lower tinidazole concentrations, since CYP3A4 contributes to tinidazole metabolism. Reduced exposure could lead to treatment failure of the infection.
How serious is the interaction between Apalutamide and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to tinidazole and consider an alternative antimicrobial if response is inadequate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
