相互作用
Hydroxychloroquine + Thioridazine
重症度: 併用禁忌
Hydroxychloroquine and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine is strongly associated with QT prolongation and torsades de pointes, and hydroxychloroquine adds to the risk. Thioridazine labeling contraindicates use with other drugs that prolong the QT interval.
この相互作用をわかりやすく説明すると
Hydroxychloroquine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation via potassium channel blockade.
対処法
Do not combine; use an alternative antipsychotic or a different antimalarial or antirheumatic agent.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HydroxychloroquineとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydroxychloroquineのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Hydroxychloroquine with Thioridazine?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with QT prolongation and torsades de pointes, and hydroxychloroquine adds to the risk. Thioridazine labeling contraindicates use with other drugs that prolong the QT interval.
How serious is the interaction between Hydroxychloroquine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antipsychotic or a different antimalarial or antirheumatic agent.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
