相互作用
Azithromycin + Thioridazine
重症度: 併用禁忌
Azithromycin and Thioridazine: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation through hERG potassium channel blockade.
対処法
Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzithromycinとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Azithromycinのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Azithromycin with Thioridazine?
MediHelp rates the interaction as contraindicated. Azithromycin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is itself contraindicated with other QT-prolonging drugs. Adding azithromycin raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Azithromycin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-macrolide antibiotic with no QT effect. If unavoidable, use continuous ECG monitoring and keep electrolytes normal.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
