相互作用
Bupropion-naltrexone + Cefpirome
重症度: 中等度
Bupropion-naltrexone and Cefpirome: moderate interaction.
最終更新日
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概要
Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
この相互作用をわかりやすく説明すると
Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cefpirome belongs to Anti Bacterial.
なぜ起こるのか
Additive lowering of seizure threshold through pharmacodynamic effects.
対処法
Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bupropion-naltrexoneとCefpiromeの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bupropion-naltrexoneのその他の相互作用
Cefpiromeのその他の相互作用
よくある質問
Can I take Bupropion-naltrexone with Cefpirome?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins such as cefpirome can lower the seizure threshold, especially in renal impairment. Combined with bupropion, which is itself dose-dependently epileptogenic, seizure risk may rise.
How serious is the interaction between Bupropion-naltrexone and Cefpirome?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust cefpirome dose to renal function and avoid exceeding the lowest effective bupropion dose. Monitor for neurological symptoms.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
