相互作用
Cefotetan + Gentamicin
重症度: 中等度
Cefotetan and Gentamicin: moderate interaction.
最終更新日
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概要
Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.
この相互作用をわかりやすく説明すると
Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
なぜ起こるのか
Possible additive proximal tubular injury; mechanism is not firmly established.
対処法
Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefotetanとGentamicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gentamicinのその他の相互作用
Cefotetanのその他の相互作用
よくある質問
Can I take Cefotetan with Gentamicin?
MediHelp rates the interaction as moderate. Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.
How serious is the interaction between Cefotetan and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
