相互作用
Cefotetan + Streptomycin
重症度: 中等度
Cefotetan and Streptomycin: moderate interaction.
最終更新日
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概要
Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.
この相互作用をわかりやすく説明すると
Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
なぜ起こるのか
Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.
対処法
Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefotetanとStreptomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Streptomycinのその他の相互作用
Cefotetanのその他の相互作用
よくある質問
Can I take Cefotetan with Streptomycin?
MediHelp rates the interaction as moderate. Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.
How serious is the interaction between Cefotetan and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
