相互作用
Clotrimazole + Everolimus
重症度: 中等度
Clotrimazole and Everolimus: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Clotrimazole (oral troche and vaginal products with systemic absorption) can inhibit CYP3A4 and P-glycoprotein and may raise everolimus levels. Higher everolimus exposure increases the risk of mucositis, infection and metabolic effects.
この相互作用をわかりやすく説明すると
Clotrimazole and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Everolimus belongs to Oncology.
なぜ起こるのか
CYP3A4 and P-gp inhibition may raise everolimus exposure
対処法
Monitor everolimus trough levels and avoid prolonged oral clotrimazole use; topical use has minimal effect.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClotrimazoleとEverolimusの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Clotrimazoleのその他の相互作用
Everolimusのその他の相互作用
よくある質問
Can I take Clotrimazole with Everolimus?
MediHelp rates the interaction as moderate. Clotrimazole and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole (oral troche and vaginal products with systemic absorption) can inhibit CYP3A4 and P-glycoprotein and may raise everolimus levels. Higher everolimus exposure increases the risk of mucositis, infection and metabolic effects.
How serious is the interaction between Clotrimazole and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough levels and avoid prolonged oral clotrimazole use; topical use has minimal effect.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
