相互作用
Cyclosporin + Red yeast rice
重症度: 重大
Cyclosporin and Red yeast rice: major interaction.
最終更新日
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概要
Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
この相互作用をわかりやすく説明すると
Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Red yeast rice belongs to Gastrointestinal Tract.
なぜ起こるのか
Cyclosporine inhibits CYP3A4 and OATP-mediated disposition of monacolin K (lovastatin), increasing its systemic levels.
対処法
Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとRed yeast riceの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Red yeast riceのその他の相互作用
よくある質問
Can I take Cyclosporin with Red yeast rice?
MediHelp rates the interaction as major. Cyclosporin and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, chemically identical to lovastatin, so cyclosporine can raise statin exposure and the risk of myopathy and rhabdomyolysis. Product content is variable and unregulated, which makes the exposure unpredictable.
How serious is the interaction between Cyclosporin and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients taking cyclosporine and use a prescribed statin with labeled dose limits if lipid lowering is needed. Report muscle pain or dark urine promptly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
