相互作用
Diflunisal + Prasugrel
重症度: 重大
Diflunisal and Prasugrel: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
この相互作用をわかりやすく説明すると
Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
なぜ起こるのか
Additive platelet inhibition (P2Y12 blockade plus COX-1 inhibition) and NSAID gastric mucosal injury.
対処法
Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DiflunisalとPrasugrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Diflunisalのその他の相互作用
Prasugrelのその他の相互作用
よくある質問
Can I take Diflunisal with Prasugrel?
MediHelp rates the interaction as major. Diflunisal and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with a potent antiplatelet increases the risk of bleeding, particularly gastrointestinal. The risk is higher with chronic NSAID use.
How serious is the interaction between Diflunisal and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel where possible and use paracetamol. If necessary, add gastroprotection and monitor for bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
