相互作用
Dronedarone + Idelalisib
重症度: 併用禁忌
Dronedarone and Idelalisib: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
この相互作用をわかりやすく説明すると
Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Idelalisib belongs to Oncology.
なぜ起こるのか
Strong CYP3A inhibition by idelalisib reduces dronedarone clearance.
対処法
Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DronedaroneとIdelalisibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Dronedaroneのその他の相互作用
Idelalisibのその他の相互作用
よくある質問
Can I take Dronedarone with Idelalisib?
MediHelp rates the interaction as contraindicated. Dronedarone and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and can sharply raise dronedarone concentrations. This increases the risk of QT prolongation, bradycardia and other adverse effects.
How serious is the interaction between Dronedarone and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; dronedarone labeling contraindicates strong CYP3A inhibitors. Use an alternative antiarrhythmic during idelalisib therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
