相互作用
Fingolimod + Mitoxantrone
重症度: 重大
Fingolimod and Mitoxantrone: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.
この相互作用をわかりやすく説明すると
Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Mitoxantrone belongs to Central Nervous System.
なぜ起こるのか
Additive immunosuppression from mitoxantrone marrow suppression and fingolimod lymphocyte sequestration.
対処法
Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FingolimodとMitoxantroneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Fingolimodのその他の相互作用
Mitoxantroneのその他の相互作用
よくある質問
Can I take Fingolimod with Mitoxantrone?
MediHelp rates the interaction as major. Fingolimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitoxantrone is myelosuppressive and immunosuppressive, and is also used in multiple sclerosis. With fingolimod, immunosuppression and infection risk may be increased, and prior mitoxantrone exposure has persistent effects.
How serious is the interaction between Fingolimod and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; when switching from mitoxantrone, check blood counts and allow recovery before starting fingolimod. Monitor for infection.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
