相互作用
Ixekizumab + Phenytoin
重症度: 軽度
Ixekizumab and Phenytoin: minor interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
この相互作用をわかりやすく説明すると
Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixekizumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
なぜ起こるのか
Normalisation of cytokine-suppressed CYP450 enzyme expression after IL-17A blockade may alter phenytoin metabolism.
対処法
Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IxekizumabとPhenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenytoinのその他の相互作用
Ixekizumabのその他の相互作用
よくある質問
Can I take Ixekizumab with Phenytoin?
MediHelp rates the interaction as minor. Ixekizumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and ixekizumab may reverse this as inflammation is controlled. Clearance of CYP substrates with a narrow therapeutic index such as phenytoin could therefore change when ixekizumab is started or stopped. The clinical effect is expected to be small.
How serious is the interaction between Ixekizumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin concentrations and clinical response when starting or stopping ixekizumab, and adjust the dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
