相互作用
Methylprednisolone + Mifepristone
重症度: 併用禁忌
Methylprednisolone and Mifepristone: contraindicated interaction.
最終更新日
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概要
Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids it may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
この相互作用をわかりやすく説明すると
Methylprednisolone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methylprednisolone belongs to Endocrine; Mifepristone belongs to Endocrine.
なぜ起こるのか
Mifepristone blocks glucocorticoid receptors, opposing the effect of methylprednisolone.
対処法
Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are required, as usual steroid doses may be ineffective.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、MethylprednisoloneとMifepristoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methylprednisoloneのその他の相互作用
- Bcg vaccine live + Methylprednisolone 併用禁忌
- Measles mumps and rubella vaccine live + Methylprednisolone 併用禁忌
- Measles mumps rubella and varicella vaccine live + Methylprednisolone 併用禁忌
- Measles vaccine + Methylprednisolone 併用禁忌
- Methylprednisolone + Rubella vaccine 併用禁忌
- Methylprednisolone + Smallpox vaccine live 併用禁忌
Mifepristoneのその他の相互作用
よくある質問
Can I take Methylprednisolone with Mifepristone?
MediHelp rates the interaction as contraindicated. Methylprednisolone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist and can blunt the effect of corticosteroids. In patients on long-term corticosteroids it may cause adrenal insufficiency or loss of disease control, and labeling lists chronic corticosteroid therapy as a contraindication.
How serious is the interaction between Methylprednisolone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use mifepristone in patients on long-term corticosteroid therapy. Seek specialist advice if both are required, as usual steroid doses may be ineffective.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
