Referência de medicamentos
Ephedrine
Ephedrine is a medicine in the class cardiovascular. It is used for hypotension.
- Classe do medicamento: Cardiovascular
- Indicado para: hypotension
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Cardiovascular
- Formas farmacêuticas comuns
- comprimido, injeção
- Concentrações comuns
- 5 mg/ml, 12.5 mg, 25 mg
- Interações conhecidas
- 170 (Contraindicada: 6 · Grave: 6 · Moderada: 88 · Leve: 70)
- Nomes comerciais
- 5
- Países e mercados
- 2
Para que é usado
Como funciona
Sympathomimetic amine that directly agonizes alpha- and beta-adrenergic receptors and indirectly causes norepinephrine release from sympathetic neurons, raising arterial pressure, cardiac output and peripheral resistance.
Dose habitual em adultos (resumo da bula)
Clinically important hypotension in the setting of anesthesia: initial 5 mg to 10 mg IV bolus; additional boluses as needed; titrate to blood pressure goal; total not to exceed 50 mg
Gravidez e amamentação
- Gravidez
- Unknown Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity.
- Amamentação
- Unknown Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
Efeitos adversos relatados
- Nausea
- Vomiting
- Tachycardia
- Palpitations
- Reactive hypertension
- Bradycardia
Contraindicações
- None
Quem deve ter cuidado
- Serious postpartum hypertension, some with stroke, reported with vasopressor plus oxytocic; monitor blood pressure carefully.
- Repeated administration can cause tachyphylaxis; have an alternative pressor ready.
- Prophylactic use to prevent hypotension is associated with increased incidence of hypertension compared with treatment of hypotension.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (170)
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
- Caffeine + Ephedrine Major
- Ephedrine + Ergotamine Major
- Ephedrine + Linezolid Major
- Ephedrine + Maprotiline Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- IV preparation and dilution
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Perguntas frequentes
What is Ephedrine used for?
Ephedrine is a medicine in the class cardiovascular. It is used for Hypotension.
What side effects have been reported with Ephedrine?
Nausea, Vomiting, Tachycardia, Palpitations, Reactive hypertension, Bradycardia.
Can Ephedrine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity. Breastfeeding: Unknown. Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
What does Ephedrine interact with?
MediHelp lists 170 known interactions for Ephedrine. Contraindicated: 6 · Major: 6 · Moderate: 88 · Minor: 70. The most serious include Isocarboxazid, Phenelzine, Procarbazine.
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