Interações medicamentosas
Ephedrine + Phenelzine
Gravidade: Contraindicada
Ephedrine and Phenelzine: contraindicated interaction.
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Resumo
Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.
O que esta interação significa em palavras simples
Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.
Por que acontece
MAO inhibition prevents norepinephrine breakdown, amplifying the indirect sympathomimetic action of ephedrine.
O que fazer
Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Outras interações de Ephedrine
- Ephedrine + Isocarboxazid Contraindicada
- Ephedrine + Procarbazine Contraindicada
- Ephedrine + Rasagiline Contraindicada
- Ephedrine + Selegiline Contraindicada
- Ephedrine + Tranylcypromine Contraindicada
- Caffeine + Ephedrine Grave
Perguntas frequentes
Can I take Ephedrine with Phenelzine?
MediHelp rates the interaction as contraindicated. Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.
How serious is the interaction between Ephedrine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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