Interações medicamentosas
Ephedrine + Maprotiline
Gravidade: Grave
Ephedrine and Maprotiline: major interaction.
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Resumo
Maprotiline can change the response to ephedrine, usually enhancing pressor and cardiac effects, though the response is unpredictable. This may cause hypertension, tachycardia or arrhythmia.
O que esta interação significa em palavras simples
Ephedrine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ephedrine belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.
Por que acontece
Maprotiline blocks norepinephrine reuptake and interferes with uptake of indirect-acting sympathomimetics into adrenergic neurons, altering the pressor response.
O que fazer
Avoid ephedrine-containing products where possible. If ephedrine is needed, start with low doses and monitor blood pressure and heart rate closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Maprotiline
- Arsenic trioxide + Maprotiline Contraindicada
- Disopyramide + Maprotiline Contraindicada
- Dofetilide + Maprotiline Contraindicada
- Ibutilide + Maprotiline Contraindicada
- Isocarboxazid + Maprotiline Contraindicada
- Maprotiline + Methylene blue Contraindicada
Outras interações de Ephedrine
- Ephedrine + Isocarboxazid Contraindicada
- Ephedrine + Phenelzine Contraindicada
- Ephedrine + Procarbazine Contraindicada
- Ephedrine + Rasagiline Contraindicada
- Ephedrine + Selegiline Contraindicada
- Ephedrine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Ephedrine with Maprotiline?
MediHelp rates the interaction as major. Ephedrine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Maprotiline can change the response to ephedrine, usually enhancing pressor and cardiac effects, though the response is unpredictable. This may cause hypertension, tachycardia or arrhythmia.
How serious is the interaction between Ephedrine and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine-containing products where possible. If ephedrine is needed, start with low doses and monitor blood pressure and heart rate closely.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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