Interações medicamentosas
Ephedrine + Isocarboxazid
Gravidade: Contraindicada
Ephedrine and Isocarboxazid: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
O que esta interação significa em palavras simples
Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Ephedrine releases norepinephrine from nerve terminals that are loaded because of MAO inhibition, and metabolism is reduced, producing exaggerated pressor effects.
O que fazer
Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
Outras interações de Ephedrine
- Ephedrine + Phenelzine Contraindicada
- Ephedrine + Procarbazine Contraindicada
- Ephedrine + Rasagiline Contraindicada
- Ephedrine + Selegiline Contraindicada
- Ephedrine + Tranylcypromine Contraindicada
- Caffeine + Ephedrine Grave
Perguntas frequentes
Can I take Ephedrine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
How serious is the interaction between Ephedrine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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