Interações medicamentosas
Bictegravir + Magnesium hydroxide
Gravidade: Moderada
Bictegravir and Magnesium hydroxide: moderate interaction.
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Resumo
Magnesium-containing antacids bind bictegravir in the gut and lower its absorption, which may reduce antiviral efficacy and risk virologic failure or resistance. The effect depends on the timing of the doses.
O que esta interação significa em palavras simples
Bictegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Divalent magnesium cations chelate the integrase inhibitor in the GI tract, reducing absorption.
O que fazer
Take bictegravir at least 2 hours before magnesium antacids under fasting conditions. Avoid taking them together or taking the antacid within 2 hours before bictegravir.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Magnesium hydroxide
Perguntas frequentes
Can I take Bictegravir with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Bictegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids bind bictegravir in the gut and lower its absorption, which may reduce antiviral efficacy and risk virologic failure or resistance. The effect depends on the timing of the doses.
How serious is the interaction between Bictegravir and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir at least 2 hours before magnesium antacids under fasting conditions. Avoid taking them together or taking the antacid within 2 hours before bictegravir.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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