Interações medicamentosas
Caspofungin + Phenytoin
Gravidade: Moderada
Caspofungin and Phenytoin: moderate interaction.
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Resumo
Phenytoin, an enzyme inducer, may lower caspofungin exposure. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
O que esta interação significa em palavras simples
Caspofungin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Phenytoin belongs to Central Nervous System.
Por que acontece
Phenytoin induces hepatic enzymes and possibly transport pathways, increasing caspofungin clearance.
O que fazer
Consider caspofungin 70 mg daily after the loading dose in adults when given with phenytoin, and monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Caspofungin
- Apalutamide + Caspofungin Moderada
- Carbamazepine + Caspofungin Moderada
- Caspofungin + Cyclosporin Moderada
- Caspofungin + Cyclosporine Moderada
- Caspofungin + Dexamethasone Moderada
- Caspofungin + Efavirenz Moderada
Outras interações de Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicada
- Bictegravir + Phenytoin Contraindicada
- Cabotegravir + Phenytoin Contraindicada
- Doravirine + Phenytoin Contraindicada
- Elbasvir / grazoprevir + Phenytoin Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicada
Perguntas frequentes
Can I take Caspofungin with Phenytoin?
MediHelp rates the interaction as moderate. Caspofungin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, an enzyme inducer, may lower caspofungin exposure. Reduced antifungal exposure could compromise treatment of invasive fungal infection.
How serious is the interaction between Caspofungin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider caspofungin 70 mg daily after the loading dose in adults when given with phenytoin, and monitor clinical response.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
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