Interações medicamentosas
Cefazolin + Streptomycin
Gravidade: Moderada
Cefazolin and Streptomycin: moderate interaction.
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Resumo
Combining cefazolin with streptomycin may increase the chance of renal injury, particularly in patients with reduced kidney function or dehydration. Streptomycin itself carries vestibular and cochlear toxicity, so any added renal impairment can raise drug exposure and worsen ototoxicity.
O que esta interação significa em palavras simples
Cefazolin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefazolin belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxic potential; reduced renal clearance of streptomycin can increase its toxicity.
O que fazer
Monitor renal function and streptomycin levels, and assess hearing and balance during therapy. Adjust the streptomycin dose for renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefazolin
- Amikacin + Cefazolin Moderada
- Bcg vaccine live + Cefazolin Moderada
- Cefazolin + Cholera vaccine Moderada
- Cefazolin + Dexamethasone-tobramycin Moderada
- Cefazolin + Gentamicin Moderada
- Cefazolin + Kanamycin Moderada
Outras interações de Streptomycin
Perguntas frequentes
Can I take Cefazolin with Streptomycin?
MediHelp rates the interaction as moderate. Cefazolin and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining cefazolin with streptomycin may increase the chance of renal injury, particularly in patients with reduced kidney function or dehydration. Streptomycin itself carries vestibular and cochlear toxicity, so any added renal impairment can raise drug exposure and worsen ototoxicity.
How serious is the interaction between Cefazolin and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and streptomycin levels, and assess hearing and balance during therapy. Adjust the streptomycin dose for renal function.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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