Interações medicamentosas
Cefepime + Streptomycin
Gravidade: Moderada
Cefepime and Streptomycin: moderate interaction.
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Resumo
Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
O que esta interação significa em palavras simples
Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Por que acontece
Additive renal tubular stress; the aminoglycoside accumulates in proximal tubular and inner ear cells and any reduction in renal function raises its exposure.
O que fazer
Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefepime
- Amikacin + Cefepime Moderada
- Cefepime + Cholera vaccine Moderada
- Cefepime + Dexamethasone-tobramycin Moderada
- Cefepime + Gentamicin Moderada
- Cefepime + Kanamycin Moderada
- Cefepime + Microbiota Moderada
Outras interações de Streptomycin
Perguntas frequentes
Can I take Cefepime with Streptomycin?
MediHelp rates the interaction as moderate. Cefepime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides are nephrotoxic and ototoxic, and combining them with a cephalosporin has been associated with additional kidney injury in some reports. Cefepime itself carries little direct nephrotoxicity, so the added risk is modest and mainly relevant in patients with existing renal impairment or prolonged therapy.
How serious is the interaction between Cefepime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin concentrations, and adjust the dose to renal function. Watch for hearing or vestibular symptoms and limit the duration of combined therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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