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Interações medicamentosas

Cefalexin + Plazomicin

Gravidade: Moderada

Cefalexin and Plazomicin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.

O que esta interação significa em palavras simples

Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefalexin belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Additive nephrotoxic potential, with reduced renal clearance increasing aminoglycoside accumulation and ototoxicity.

O que fazer

Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefalexin with Plazomicin?

MediHelp rates the interaction as moderate. Cefalexin and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with labeled risks of nephrotoxicity and ototoxicity. Other agents that can impair renal function, including cephalosporins in some reports, may add to kidney injury and raise plazomicin exposure.

How serious is the interaction between Cefalexin and Plazomicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations, and adjust dosing to renal function per labeling. Watch for hearing loss, tinnitus or vestibular symptoms.

What other medicines interact with Cefalexin?

MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.

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