Interações medicamentosas
Deutetrabenazine + Phenelzine
Gravidade: Contraindicada
Deutetrabenazine and Phenelzine: contraindicated interaction.
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Resumo
Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
O que esta interação significa em palavras simples
Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
VMAT2 inhibition alters monoamine storage while MAO inhibition prevents their breakdown, causing unpredictable monoamine and pressor effects.
O que fazer
Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Outras interações de Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicada
- Deutetrabenazine + Linezolid Contraindicada
- Deutetrabenazine + Rasagiline Contraindicada
- Deutetrabenazine + Safinamide Contraindicada
- Deutetrabenazine + Selegiline Contraindicada
- Deutetrabenazine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Deutetrabenazine with Phenelzine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
How serious is the interaction between Deutetrabenazine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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