Interações medicamentosas
Deutetrabenazine + Safinamide
Gravidade: Contraindicada
Deutetrabenazine and Safinamide: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
O que esta interação significa em palavras simples
Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Por que acontece
Vesicular monoamine depletion by deutetrabenazine together with MAO inhibition causes unstable catecholamine effects.
O que fazer
Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Safinamide
- Amitriptyline + Safinamide Contraindicada
- Amoxapine + Safinamide Contraindicada
- Amphetamine polistirex + Safinamide Contraindicada
- Clomipramine + Safinamide Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Desipramine + Safinamide Contraindicada
Outras interações de Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicada
- Deutetrabenazine + Linezolid Contraindicada
- Deutetrabenazine + Phenelzine Contraindicada
- Deutetrabenazine + Rasagiline Contraindicada
- Deutetrabenazine + Selegiline Contraindicada
- Deutetrabenazine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Deutetrabenazine with Safinamide?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.
How serious is the interaction between Deutetrabenazine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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