Interações medicamentosas
Deutetrabenazine + Selegiline
Gravidade: Contraindicada
Deutetrabenazine and Selegiline: contraindicated interaction.
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Resumo
Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
O que esta interação significa em palavras simples
Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Por que acontece
Deutetrabenazine depletes and releases monoamines while MAO inhibition blocks their breakdown, so catecholamines can accumulate and cause a pressor response.
O que fazer
Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Selegiline
- Amitriptyline + Selegiline Contraindicada
- Amoxapine + Selegiline Contraindicada
- Atomoxetine + Selegiline Contraindicada
- Benzphetamine + Selegiline Contraindicada
- Brimonidine + Selegiline Contraindicada
- Buprenorphine long-acting + Selegiline Contraindicada
Outras interações de Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicada
- Deutetrabenazine + Linezolid Contraindicada
- Deutetrabenazine + Phenelzine Contraindicada
- Deutetrabenazine + Rasagiline Contraindicada
- Deutetrabenazine + Safinamide Contraindicada
- Deutetrabenazine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Deutetrabenazine with Selegiline?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.
How serious is the interaction between Deutetrabenazine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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