Interações medicamentosas
Dexmethylphenidate + Safinamide
Gravidade: Contraindicada
Dexmethylphenidate and Safinamide: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
O que esta interação significa em palavras simples
Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Por que acontece
MAO inhibition reduces catecholamine breakdown while the stimulant increases catecholamine release and blocks reuptake, producing additive sympathomimetic effects.
O que fazer
Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Safinamide
- Amitriptyline + Safinamide Contraindicada
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- Amphetamine polistirex + Safinamide Contraindicada
- Clomipramine + Safinamide Contraindicada
- Cyclobenzaprine + Safinamide Contraindicada
- Desipramine + Safinamide Contraindicada
Outras interações de Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicada
- Dexmethylphenidate + Linezolid Contraindicada
- Dexmethylphenidate + Phenelzine Contraindicada
- Dexmethylphenidate + Procarbazine Contraindicada
- Dexmethylphenidate + Rasagiline Contraindicada
- Dexmethylphenidate + Selegiline Contraindicada
Perguntas frequentes
Can I take Dexmethylphenidate with Safinamide?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
How serious is the interaction between Dexmethylphenidate and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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