Interações medicamentosas
Dexmethylphenidate + Procarbazine
Gravidade: Contraindicada
Dexmethylphenidate and Procarbazine: contraindicated interaction.
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Resumo
Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
O que esta interação significa em palavras simples
Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Procarbazine belongs to Oncology.
Por que acontece
MAO inhibition increases stores of catecholamines, so the sympathomimetic effects of the stimulant are exaggerated.
O que fazer
Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amoxapine + Procarbazine Contraindicada
- Atomoxetine + Procarbazine Contraindicada
- Bcg vaccine live + Procarbazine Contraindicada
- Brimonidine + Procarbazine Contraindicada
Outras interações de Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicada
- Dexmethylphenidate + Linezolid Contraindicada
- Dexmethylphenidate + Phenelzine Contraindicada
- Dexmethylphenidate + Rasagiline Contraindicada
- Dexmethylphenidate + Safinamide Contraindicada
- Dexmethylphenidate + Selegiline Contraindicada
Perguntas frequentes
Can I take Dexmethylphenidate with Procarbazine?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
How serious is the interaction between Dexmethylphenidate and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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