Interações medicamentosas
Dihydroergotamine + Nitroglycerin
Gravidade: Grave
Dihydroergotamine and Nitroglycerin: major interaction.
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Resumo
Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
O que esta interação significa em palavras simples
Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Nitroglycerin belongs to Cardiovascular.
Por que acontece
Opposing vasoactive effects, with possible increased dihydroergotamine exposure caused by nitrates.
O que fazer
Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Nitroglycerin
- Avanafil + Nitroglycerin Contraindicada
- Nitroglycerin + Riociguat Contraindicada
- Nitroglycerin + Sildenafil Contraindicada
- Nitroglycerin + Tadalafil Contraindicada
- Nitroglycerin + Vardenafil Contraindicada
- Dihydroergotamine intranasal + Nitroglycerin Grave
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Nitroglycerin?
MediHelp rates the interaction as major. Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
How serious is the interaction between Dihydroergotamine and Nitroglycerin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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