Interações medicamentosas
Glycerol phenylbutyrate + Methylprednisolone
Gravidade: Moderada
Glycerol phenylbutyrate and Methylprednisolone: moderate interaction.
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Resumo
Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
O que esta interação significa em palavras simples
Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
Por que acontece
Glucocorticoid-induced protein catabolism increases nitrogen load and ammonia production, opposing the nitrogen-scavenging effect.
O que fazer
Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicada
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicada
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicada
- Measles vaccine + Methylprednisolone Contraindicada
- Methylprednisolone + Mifepristone Contraindicada
- Methylprednisolone + Rubella vaccine Contraindicada
Outras interações de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Grave
- Glycerol phenylbutyrate + Sodium valproate Grave
- Glycerol phenylbutyrate + Valproic acid Grave
- Cyclosporin + Glycerol phenylbutyrate Moderada
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderada
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderada
Perguntas frequentes
Can I take Glycerol phenylbutyrate with Methylprednisolone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise plasma ammonia. This may counteract the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders and risk hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting or changing corticosteroid therapy and adjust glycerol phenylbutyrate dosing as needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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