Interações medicamentosas
Isotretinoin + Tetracycline
Gravidade: Grave
Isotretinoin and Tetracycline: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Both isotretinoin and tetracycline-class antibiotics can cause benign intracranial hypertension (pseudotumor cerebri). Used together, the risk of headache, visual disturbance, and papilledema may be increased, with a risk of permanent visual loss if unrecognized. The isotretinoin label advises against concomitant use.
O que esta interação significa em palavras simples
Isotretinoin and Tetracycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isotretinoin belongs to Dermatology; Tetracycline belongs to Anti Bacterial.
Por que acontece
Additive pharmacodynamic effect on raising intracranial pressure; the exact mechanism of each drug is not fully established.
O que fazer
Avoid concomitant use; if an antibiotic is needed during isotretinoin therapy, choose a non-tetracycline option. If the patient must stop tetracycline, allow it to be discontinued before isotretinoin starts.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Isotretinoin
- Demeclocycline + Isotretinoin Contraindicada
- Isotretinoin + Minocycline Contraindicada
- Isotretinoin + Oxytetracycline Contraindicada
- Isotretinoin + Palovarotene Contraindicada
- Aminolevulinic acid + Isotretinoin Grave
- Doxycycline + Isotretinoin Grave
Outras interações de Tetracycline
- Acitretin + Tetracycline Contraindicada
- Methoxyflurane + Tetracycline Contraindicada
- Palovarotene + Tetracycline Grave
- Strontium ranelate + Tetracycline Grave
- Tetracycline + Tretinoin Grave
- Tetracycline + Typhoid vaccine live Grave
Perguntas frequentes
Can I take Isotretinoin with Tetracycline?
MediHelp rates the interaction as major. Isotretinoin and Tetracycline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both isotretinoin and tetracycline-class antibiotics can cause benign intracranial hypertension (pseudotumor cerebri). Used together, the risk of headache, visual disturbance, and papilledema may be increased, with a risk of permanent visual loss if unrecognized. The isotretinoin label advises against concomitant use.
How serious is the interaction between Isotretinoin and Tetracycline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if an antibiotic is needed during isotretinoin therapy, choose a non-tetracycline option. If the patient must stop tetracycline, allow it to be discontinued before isotretinoin starts.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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