Interações medicamentosas
Oxytocin + Phenylephrine
Gravidade: Grave
Oxytocin and Phenylephrine: major interaction.
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Resumo
Oxytocin may cause hypotension, while vasopressors given with it can cause severe hypertension. Labeling for oxytocin warns that vasoconstrictors given with it can lead to hypertensive episodes.
O que esta interação significa em palavras simples
Oxytocin and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxytocin belongs to Endocrine; Phenylephrine belongs to Respiratory.
Por que acontece
Additive pharmacodynamic effects; oxytocin-related vascular changes combined with alpha-1 vasoconstriction.
O que fazer
Monitor blood pressure closely, for example during obstetric anesthesia, and titrate phenylephrine in small doses.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicada
- Phenelzine + Phenylephrine Contraindicada
- Phenylephrine + Tranylcypromine Contraindicada
- Bromocriptine + Phenylephrine Grave
- Cocaine + Phenylephrine Grave
- Dihydroergotamine intranasal + Phenylephrine Grave
Outras interações de Oxytocin
- Carboprost tromethamine + Oxytocin Grave
- Dinoprostone + Oxytocin Grave
- Ephedrine + Oxytocin Grave
- Fexinidazole + Oxytocin Grave
- Givinostat + Oxytocin Grave
- Misoprostol + Oxytocin Grave
Perguntas frequentes
Can I take Oxytocin with Phenylephrine?
MediHelp rates the interaction as major. Oxytocin and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxytocin may cause hypotension, while vasopressors given with it can cause severe hypertension. Labeling for oxytocin warns that vasoconstrictors given with it can lead to hypertensive episodes.
How serious is the interaction between Oxytocin and Phenylephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, for example during obstetric anesthesia, and titrate phenylephrine in small doses.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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